Your memory is no video camera: It edits the past with present experiences

Your memory is a wily time traveller, plucking fragments of the present and inserting them into the past, reports a new study. In terms of accuracy, it's no video camera. Rather, memory rewrites the past with current information, updating your recollections with new experiences to aid survival. Love at first sight, for example, is more likely a trick of your memory than a Hollywood-worthy moment.

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Your memory is a wily time traveller, plucking fragments of the present and inserting them into the past, reports a new North western Medicine® study. In terms of accuracy, it's no video camera.

Rather, the memory rewrites the past with current information, updating your recollections with new experiences.

Love at first sight, for example, is more likely a trick of your memory than a Hollywood-worthy moment."When you think back to when you met your current partner, you may recall this feeling of love and euphoria," said lead author Donna Jo Bridge, a post doctoral fellow in medical social sciences at North western University Feinberg School of Medicine. "But you may be projecting your current feelings back to the original encounter with this person."

This the first study to show specifically how memory is faulty, and how it can insert things from the present into memories of the past when those memories are retrieved. The study shows the exact point in time when that incorrectly recalled information gets implanted into an existing memory.

To help us survive, Bridge said, our memories adapt to an ever-changing environment and help us deal with what's important now.

"Our memory is not like a video camera," Bridge said. "Your memory re frames and edits events to create a story to fit your current world. It's built to be current."

All that editing happens in the hippo campus, the new study found. The hippo campus, in this function, is the memory's equivalent of a film editor and special effects team.

For the experiment, 17 men and women studied 168 object locations on a computer screen with varied backgrounds such as an underwater ocean scene or an aerial view of Midwest farmland. Next, researchers asked participants to try to place the object in the original location but on a new background screen. Participants would always place the objects in an incorrect location.

For the final part of the study, participants were shown the object in three locations on the original screen and asked to choose the correct location. Their choices were: the location they originally saw the object, the location they placed it in part 2 or a brand new location.

"People always chose the location they picked in part 2," Bridge said. "This shows their original memory of the location has changed to reflect the location they recalled on the new background screen. Their memory has updated the information by inserting the new information into the old memory."

Participants took the test in an MRI scanner so scientists could observe their brain activity. Scientists also tracked participants' eye movements, which sometimes were more revealing about the content of their memories -- and if there was conflict in their choices -- than the actual location they ended up choosing.

The notion of a perfect memory is a myth, said Joel Voss, senior author of the paper and an assistant professor of medical social sciences and of neurology at Feinberg.

"Everyone likes to think of memory as this thing that lets us vividly remember our childhoods or what we did last week," Voss said. "But memory is designed to help us make good decisions in the moment and, therefore, memory has to stay up-to-date. The information that is relevant right now can overwrite what was there to begin with."

Bridge noted the study's implications for eyewitness court testimony. "Our memory is built to change, not regurgitate facts, so we are not very reliable witnesses," she said.

A caveat of the research is that it was done in a controlled experimental setting and shows how memories changed within the experiment. "Although this occurred in a laboratory setting, it's reasonable to think the memory behaves like this in the real world," Bridge said.

Nature can, selectively, buffer human-caused global warming, say scientists

Nature can, selectively, buffer human-caused global warming, say scientists

Can naturally occurring processes selectively buffer the full brunt of global warming caused by greenhouse gas emissions resulting from human activities? Yes, says a group of researchers in a new study.

Can naturally occurring processes selectively buffer the full brunt of global warming caused by greenhouse gas emissions resulting from human activities?

Yes, find researchers from the Hebrew University of Jerusalem, Johns Hopkins University in the US and NASA's Goddard Space Flight Centre.

As the globe warms, ocean temperatures rise, leading to increased water vapour escaping into the atmosphere. Water vapour is the most important greenhouse gas, and its impact on climate is amplified in the stratosphere.

In a detailed study, the researchers from the three institutions examined the causes of changes in the temperatures and water vapour in the tropical troposphere layer (TTL). The TTL is a critical region of our atmosphere with characteristics of both the troposphere below and the stratosphere above.

The TTL can have significant influences on both atmospheric chemistry and climate, as its temperature determines how much water vapour can enter the stratosphere. Therefore, understanding any changes in the temperature of the TTL and what might be causing them is an important scientific question of significant societal relevance, say the researchers.

The Israeli and US scientists used measurements from satellite observations and output from chemistry-climate models to understand recent temperature trends in the TTL. Temperature measurements show where significant changes have taken place since 1979.

The satellite observations have shown that warming of the tropical Indian Ocean and tropical Western Pacific Ocean -- with resulting increased precipitation and water vapour there -- causes the opposite effect of cooling in the TTL region above the warming sea surface. Once the TTL cools, less water vapor is present in the TTL and also above in the stratosphere.

Since water vapor is a very strong greenhouse gas, this effect leads to a negative feedback on climate change. That is, the increase in water vapour due to enhanced evaporation from the warming oceans is confined to the near- surface area, while the stratosphere becomes drier. Hence, this effect may actually slightly weaken the more dire forecaster aspects of an increasing warming of our climate, the scientists say.

The researchers are Dr. Chaim Garfinkel of the Fredy and Nadine Herrmann Institute of Earth Sciences at the Hebrew University and formerly of Johns Hopkins University, Dr. D. W. Waugh and Dr. L. Wang of Johns Hopkins, and Dr. L. D. Oman and Dr. M. M. Hurwitz of the Goddard Space Flight Centre. Their findings have been published in the Journal of Geophysical Research: Atmosphere, and the research was also highlighted in Nature Climate Change.

Making color: When two red photons make a blue photon

Making color: When two red photons make a blue photon

Can scientists generate any color of light? The answer is not really, but the invention of the laser in 1960 opened new doors for this endeavor. Scientists have now demonstrated a new semiconductor microstructure that performs frequency conversion. This design is a factor of 1000 smaller than previous devices.

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Color is strange, mainly due to perception. Setting aside complex brain processes, what we see is the result of light absorption, emission, and reflection. Trees appear green because atoms inside the leaves are emitting and/or reflecting green photons. Semiconductor LED brake lights emit single color light when electrical current passes through the devices.

Here's a question: Can scientists generate any color of light? The answer is not really, but the invention of the laser in 1960 opened new doors for this endeavor. An early experiment injected high-power laser light through quartz and out popped a different color. This sparked the field of nonlinear optics and with it, a new method of color generation became possible: frequency conversion.

Not all crystals can perform this trick and only through careful fabrication of certain materials is frequency conversion possible. In a result published in Nature Communications, scientists demonstrate a new microstructure that does what's called second harmonic generation (SHG), where the output light has twice the frequency as the input. This new device is a factor of 1000 smaller than previous frequency converters.

You can't really get something from nothing here. Physics demands that both energy and momentum are conserved in the frequency-doubling process. The energy of light is directly related to its frequency through a fundamental constant, thus this conservation law is automatically satisfied. Two photons of fixed energy pass into the conversion crystal and the output photon has a frequency, thus energy, equal to their sum.

The challenging part is momentum conservation and achieving it takes careful engineering. This difficulty arises because light has an associated direction of travel. Materials bend and delay light, and how it occurs is very material dependent. Even more, different frequencies (colors) are bent and delayed differently by a given material. This is called dispersion and is perhaps most familiar as a rainbow, where the constituent colors of sunlight are separated.

Even with dispersion, some materials have naturally occurring refractive properties that allow momentum-matching, and thus frequency conversion. Until about 20 years ago, these materials were the only option for frequency conversion. In the 1990s, scientists began to tackle the momentum conservation issue using a technique called quasi-phase matching (QPM).

When a light wave enters and moves through a crystal its properties such as velocity are altered depending on its color. In the case of second-harmonic generation, the injection light strongly interacts with the medium and a second color, having twice the frequency, is generated. Due to dispersion, the second light wave will be delayed. In QPM, scientists vary the spacing and orientation between the internal crystal layers to compensate for the delay, such that momentum conservation between the injection and output light is conserved. This method of QPM is successful but can be difficult from a fabrication point-of-view. Moreover, miniaturizing their overall size for integration onto chips is limited. This is because the frequency conversion process depends on the physical length of the interaction medium, thus scaling down these types of crystals will lead to an inherent reduction in efficiency.

Now this team has demonstrated a new, arguably simpler way, to achieve QPM and thus frequency conversion. In the new design, gallium arsenide (GaAs) is fabricated into a micrometer-sized disk 'whispering gallery' cavity. Notably, GaAs has one of the largest second-harmonic frequency conversion constants measured. Previously, scientists have harnessed its extremely nonlinear properties through the layer-varying QPM method, leading to device sizes in the centimeter range. This new device is 1000 times smaller.

In the experiment, light from a tapered optical fiber is injected into the cavity. When light travels in a loop with the proper orientation, as opposed to a linear geometry, QPM, and therefore color conversion is achieved. This team skirts around the miniaturization problem because the light can interact many times with the medium by circulating around the disk, yet the overall size can remain small. Using a cavity also means that since the power builds up in the microdisk, less injection power can be used. Think of the architectural example of a whispering gallery -- wherein sound waves add together such that small input signals (whispers) can be heard. This resonant enhancement also happens for light trapped inside microdisk cavities.

NIST scientist and author Glenn Solomon continues, "Through a combination of microcavity engineering and nonlinear optics, we can create a very small frequency conversion device that could be more easily integrated onto optical chips."

Lead author Paulina Kuo, who is currently doing research at NIST in the Information Technology Laboratory,adds, "I am excited because this method for phase-matching is brand new. It is amazing that the crystal itself can provide the phase-matching to ensure momentum conservation, and it's promising to see efficient optical frequency conversion in a really tiny volume."

In terms of future quantum information applications, the simple harmonic generation process can be considered as parametric down conversion (PDC) in reverse. PDC is a method for generating entangled photon pairs and so this device could provide a new technique for accomplishing this.

Gallium arsenide (GaAs) is a common semiconductor and has added benefits such as transmitting and emitting in the infrared (IR) and near IR light, respectively. IR-colored light has applications that include telecommunications and chemical sensing. Kuo adds, "The presence of an absorbing species affects the cavity resonance conditions and, in turn, the amount of frequency conversion in the microdisk. Thus, this device could be used in novel sensing applications."

Bones of a Previously Unknown Species Prove to be One of the Oldest Seabirds

Bones of a Previously Unknown Species Prove to be One of the Oldest Seabirds

Fossils discovered in Canterbury, New Zealand reveal the nature of one of the world's oldest flying seabirds. Thought to have lived between 60.5 and 61.6 million years ago, the fossil is suggested to have formed shortly after the extinction of dinosaurs and many marine organisms.

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Fossils discovered in Canterbury, New Zealand reveal the nature of one of the world's oldest flying seabirds. Thought to have lived between 60.5 and 61.6 million years ago, the fossil is suggested to have formed shortly after the extinction of dinosaurs and many marine organisms.

Bones of the bird were discovered in 2009 by Leigh Love, an amateur fossil collector. The new species, Australornis lovei has been named as such in honour of Love's discovery.

The bird lacks key morphological features of penguins, though it was found near the fossils of the Waimanu manneringi, the oldest penguin, of which it is also estimated to be the same age.

The research is published in Journal of the Royal Society of New Zealand by Dr Gerald Mayr and Dr Paul Scofield. The authors claim the discovery 'represents one of the most significant records of a marine Paleocene bird from the Southern Hemisphere' and supports the 'emerging view that most modern birds were already diversified in the earliest Paleogene'.

Despite the distinctness of this new species, its derived features are not limited to a single bird group. It does resemble an extinct species from Antarctica, however, highlighting the links between Antarctica and New Zealand in the late Cretaceous period.

Timing Is Everything: How the Brain Links Memories of Sequential Events

Timing Is Everything: How the Brain Links Memories of Sequential Events

Suppose you heard the sound of skidding tires, followed by a car crash. The next time you heard such a skid, you might cringe in fear, expecting a crash to follow -- suggesting that somehow, your brain had linked those two memories so that a fairly innocuous sound provokes dread.

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MIT neuroscientists have now discovered how two neural circuits in the brain work together to control the formation of such time-linked memories. This is a critical ability that helps the brain to determine when it needs to take action to defend against a potential threat, says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and senior author of a paper describing the findings in the Jan. 23 issue of Science.

"It's important for us to be able to associate things that happen with some temporal gap," says Tonegawa, who is a member of MIT's Picower Institute for Learning and Memory. "For animals it is very useful to know what events they should associate, and what not to associate."

The interaction of these two circuits allows the brain to maintain a balance between becoming too easily paralyzed with fear and being too careless, which could result in being caught off guard by a predator or other threat.

The paper's lead authors are Picower Institute postdocs Takashi Kitamura and Michele Pignatelli.

Linking memories

Memories of events, known as episodic memories, always contain three elements -- what, where, and when. Those memories are created in a brain structure called the hippocampus, which must coordinate each of these three elements.

To form episodic memories, the hippocampus also communicates with the region of the cerebral cortex just outside the hippocampus, known as the entorhinal cortex. The entorhinal cortex, which has several layers, receives sensory information, such as sights and sounds, from sensory processing areas of the brain and sends the information on to the hippocampus.

Previous research has revealed a great deal about how the brain links the place and object components of memory. Certain neurons in the hippocampus, known as place cells, are specialized to fire when an animal is in a specific location, and also when the animal is remembering that location. However, when it comes to associating objects and time, "our understanding has fallen behind," Tonegawa says. "Something is known, but relatively little compared to the object-place mechanism."

The new Science paper builds on a 2011 study from Tonegawa's lab in which he identified a brain circuit necessary for mice to link memories of two events -- a tone and a mild electric shock -- that occur up to 20 seconds apart. This circuit connects layer 3 of the entorhinal cortex to the CA1 region of the hippocampus. When that circuit, known as the monosynaptic circuit, was disrupted, the animals did not learn to fear the tone.

In the new paper, the researchers report the discovery of a previously unknown circuit that suppresses the monosynaptic circuit. This signal originates in a type of excitatory neurons discovered in Tonegawa's lab, dubbed "island cells" because they form circular clusters within layer 2. Those cells stimulate inhibitory neurons in CA1 that suppress the set of excitatory CA1 neurons that are activated by the monosynaptic circuit.

This circuit creates a counterbalance that limits the window of opportunity for two events to become linked. "This pathway might provide a mechanism for preventing constant learning of unimportant temporal associations," says Michael Hasselmo, a professor of psychology at Boston University who was not part of the research team.

The findings are "an important demonstration of the functional role of different populations of neurons in entorhinal cortex that provide input to the hippocampus," Hasselmo adds.

Deciphering circuits

The researchers used optogenetics, a technology that allows specific populations of neurons to be turned on or off with light, to demonstrate the interplay of these two circuits.

In normal mice, the maximum time gap between events that can be linked is about 20 seconds, but the researchers could lengthen that period by either boosting activity of layer 3 cells or suppressing layer 2 island cells. Conversely, they could shorten the window of opportunity by inhibiting layer 3 cells or stimulating input from layer 2 island cells, which both result in turning down CA1 activity.

The researchers hypothesize that prolonged CA1 activity keeps the memory of the tone alive long enough so that it is still present when the shock takes place, allowing the two memories to be linked. They are now investigating whether CA1 neurons remain active throughout the entire gap between events.

The research was funded by the RIKEN Brain Science Institute, the Howard Hughes Medical Institute, and the JPB Foundation.

Genome of Longest-Living Cancer: 11,000-Year-Old Living Dog Cancer Reveals Its Origin, Evolution

Genome of Longest-Living Cancer: 11,000-Year-Old Living Dog Cancer Reveals Its Origin, Evolution

A cancer normally lives and dies with a person, however this is not the case with a sexually transmitted cancer in dogs. In a study published in Science, researchers have described the genome and evolution of this cancer that has continued living within the dog population for the past 11,000 years.

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Scientists have sequenced the genome of the world's oldest continuously surviving cancer, a transmissible genital cancer that affects dogs. This cancer, which causes grotesque genital tumors in dogs around the world, first arose in a single dog that lived about 11,000 years ago. The cancer survived after the death of this dog by the transfer of its cancer cells to other dogs during mating.

The genome of this 11,000-year-old cancer carries about two million mutations -- many more mutations than are found in most human cancers, the majority of which have between 1,000 and 5,000 mutations. The team used one type of mutation, known to accumulate steadily over time as a "molecular clock," to estimate that the cancer first arose 11,000 years ago.

"The genome of this remarkable long-lived cancer has demonstrated that, given the right conditions, cancers can continue to survive for more than 10,000 years despite the accumulation of millions of mutations," says Dr Elizabeth Murchison, first author from the Wellcome Trust Sanger Institute and the University of Cambridge.

The genome of the transmissible dog cancer still harbors the genetic variants of the individual dog that first gave rise to the cancer 11,000 years ago. Analysis of these genetic variants revealed that this dog may have resembled an Alaskan Malamute or Husky. It probably had a short, straight coat that was colored either grey/brown or black. Its genetic sequence could not determine if this dog was a male or a female, but did indicate that it was a relatively inbred individual.

"We do not know why this particular individual gave rise to a transmissible cancer," says Dr Murchison, "But it is fascinating to look back in time and reconstruct the identity of this ancient dog whose genome is still alive today in the cells of the cancer that it spawned."

Transmissible dog cancer is a common disease found in dogs around the world today. The genome sequence has helped scientists to further understand how this disease has spread.

"The patterns of genetic variants in tumors from different continents suggested that the cancer existed in one isolated population of dogs for most of its history," says Dr Murchison. "It spread around the world within the last 500 years, possibly carried by dogs accompanying seafarers on their global explorations during the dawn of the age of exploration."

Transmissible cancers are extremely rare in nature. Cancers, in humans and animals, arise when a single cell in the body acquires mutations that cause it to produce more copies of itself. Cancer cells often spread to different parts of the body in a process known as metastasis. However, it is very rare for cancer cells to leave the bodies of their original hosts and to spread to other individuals. Apart from the dog transmissible cancer, the only other known naturally occurring transmissible cancer is an aggressive transmissible facial cancer in Tasmanian devils that is spread by biting.

"The genome of the transmissible dog cancer will help us to understand the processes that allow cancers to become transmissible," says Professor Sir Mike Stratton, senior author and Director of the Sanger Institute. "Although transmissible cancers are very rare, we should be prepared in case such a disease emerged in humans or other animals. Furthermore, studying the evolution of this ancient cancer can help us to understand factors driving cancer evolution more generally."

One Quarter of the World's Cartilaginous Fish, Namely Sharks and Rays, Face Imminent Extinction

One Quarter of the World's Cartilaginous Fish, Namely Sharks and Rays, Face Imminent Extinction

One quarter of the world's cartilaginous fish, namely sharks and rays, face extinction within the next few decades, according to the first study to systematically and globally assess their fate.

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The International Union for Conservation of Nature's (IUCN's) Shark Specialist Group (SSG), co-chaired by Nick Dulvy, a Simon Fraser University (SFU) Canada Research Chair in Marine Biodiversity and Conservation in British Columbia, conducted the study.

It was published ineLife journal today.Previous studies have documented local overfishing of some populations of sharks and rays. But this is the first one to survey their status through out coastal seas and oceans. It reveals that one-quarter (249) of 1,041 known shark, ray and chimaera species globally fall under three threatened categories on the IUCN Red List.

"We now know that many species of sharks and rays, not just the charismatic white sharks, face extinction across the ice-free seas of the world," says Dulvy. "There are no real sanctuaries for sharks where they are safe from overfishing."

Over two decades, the authors applied the IUCN's Red List categories and criteria to the 1,041 species at 17 workshops involving more than 300 experts. They incorporated all available information on distribution, catch, abundance, population trends, habitat use, life histories, threats and conservation measures.

Sharks and rays are at substantially higher risk of extinction than many other animals and have the lowest percentage of species considered safe. Using the IUCN Red List, the authors classified 107 species of rays (including skates) and 74 species of sharks as threatened. Just 23 percent of species were labeled as being Least Concern.

The authors identified two main hotspots for shark and ray depletion -- the Indo-Pacific (particularly the Gulf of Thailand), the Red Sea and the Mediterranean Sea.

"In the most peril are the largest species of rays and sharks, especially those living in relatively shallow water that is accessible to fisheries. The combined effects of overexploitation -- especially for the lucrative shark fin soup market -- and habit degradation are most severe for the 90 species found in freshwater.

"A whole bunch of wildly charismatic species is at risk. Rays, including the majestic manta and devil rays, are generally worse off than sharks. Unless binding commitments to protect these fish are made now, there is a real risk that our grandchildren won't see sharks and rays in the wild."

Losing these fish will be like losing whole chapters of our evolutionary history says Dulvy. "They are the only living representatives of the first lineage to have jaws, brains, placentas and the modern immune system of vertebrates."

The potential loss of the largest species is frightening for many reasons, says Dulvy. "The biggest species tend to have the greatest predatory role. The loss of top or apex predators cascades throughout marine ecosystems."

The IUCN SSG is calling on governments to safeguard sharks, rays and chimaeras through a variety of measures, including the following: prohibition on catching the most threatened species, science-based fisheries quotas, protection of key habitats and improved enforcement.